Book 01 / Healthspan & evidence
The Longevity Operating System
Mark A. Smith
A Practical, Evidence-Literate Guide to Healthspan, Measurement, and Self-Experimentation
Independent thinking. Open knowledge.
Green Man Longevity.
Four books by Mark A. Smith. One shared question: what does the evidence really tell us about living well for longer?
Mark A. Smith / The Longevity Evidence Series
Four perspectives. A clearer picture.
Healthspan. Muscle. Brain health. Metabolism. All four free editions, without a paywall.
Book 02 / Rapamycin & muscle
mTOR, Metabolism, and Muscle
Mark A. Smith
Rapamycin, Exercise, and the Biology of Longevity Trade-offs
Book 03 / Brain health & prevention
Outrunning Alzheimer’s
Mark A. Smith
What a Global Longevity Community Tested—and What the Evidence Now Says About Protecting Your Brain
Book 04 / GLP-1 & metabolic health
The Metabolic Frontier
Mark A. Smith
GLP-1 Medicines, Emerging Peptides, Gray-Market Risks, and the Science of Better Body Composition
The thread through the collection
Evidence before enthusiasm.
Animal findings are not human outcomes. Forum experiences are not controlled trials. A promising mechanism is not a prescription. These books examine the possibilities—and keep the uncertainty in view.
The research library
Follow the evidence.
Selected publications behind the conversations, with their limits in plain view.
RapamycinHuman trial
Rapamycin, mTOR & the biology of aging
What research into mTOR inhibition can tell us about immune function and healthy aging.
Science Translational Medicine · 2014
GLP-1Human trial
GLP-1 benefits beyond weight loss
A closer look at semaglutide and the cardiovascular findings from the SELECT trial.
New England Journal of Medicine · 2023
Brain healthEvidence review
A lifelong approach to brain health
Understanding the modifiable risk factors for Alzheimer’s disease and dementia.
The Lancet · 2024